01/2023 journal articles
NUTRITIONAL STATUS AND ANTICHOLINERGIC BURDEN IN OLDER PATIENTS LIVING IN NURSING HOMES: RESULTS FROM THE IDEM STUDY
A. Jullien, A. Pagès, C. Cantet, G. Soriano, L. Rouch, C. Cool, S. Andrieu, N. Tavassoli, P. Cestac, Y. Rolland, C. McCambridge
Jour Nursing Home Res 2023;9:1-8Show summaryHide summary
Background: Drugs with anticholinergic properties have many adverse effects that can affect nutritional status. Methods: An observational cross-sectional study was conducted on data from the IDEM study (N=585) to explore the link between nutritional status and anticholinergic burden as well as other factors among older nursing home residents. Nutritional status was determined using the Mini Nutritional Assessment. Multivariate logistic mixed regression was used. Results: Half of residents (N=293) had an impaired nutritional status. After adjusting for potential confounders, there was no significant association between high anticholinergic burden and impaired nutritional status. However, the impaired nutritional status was significantly higher for women (OR=1.90, 95CI=[1.15–3.15]), patients with a high Charlson Comorbidity Index score (OR=2.22, 95CI=[1.12–4.38]), history of fracture (OR=1.62, 95CI = [1.03–2.54]) or abnormal one-leg standing test (OR=1.99, 95CI=[1.04–3.78]), a low cognitive score (OR=0.95, 95CI=[0.91–1.00]), with a low autonomy scale (GIR) (OR=0.69, 95CI=[0.57–0.85]) and with a poor Quality of Life-Alzheimer’s Disease assessment (OR=0.90, 95CI=[0.86–0.94]). Conclusions: We found no significant association between anticholinergic exposure and nutritional status in older residents living in nursing homes. The use of existing scales in clinical practice remains a challenge because of the complexity of calculating anticholinergic exposure.
A. Jullien ; A. Pagès ; C. Cantet ; G. Soriano ; L. Rouch ; C. Cool ; S. Andrieu ; N. Tavassoli ; P. Cestac ; Y. Rolland ; C. McCambridge (2023): Nutritional status and anticholinergic burden in older patients living in nursing homes: results from the IDEM study. The Journal of Nursing Home Research Science (JNHRS). http://dx.doi.org/10.14283/jnhrs.2023.1
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